![]() We fit interaction terms between VPA volume and light and moderate volume, separately. 21, 22 We used bootstrapping with replacement (1000 iterations) to calculate CIs for the optimal and minimal dose. To provide conservative point estimates for associations, we assessed the minimal dose, defined as the volume of VPA associated with 50% of the lowest HR (‘optimal dose’ nadir of the dose curve). Additional time-to-event analyses were performed to examine associations with mortality and incident disease across lifestyle and health variable groups. 20 The E-values indicate the required magnitude of the association unmeasured confounders to reduce findings to null. We calculated E-values to estimate the plausibility of bias from unmeasured confounding. For both absolute risk and HR analyses, departure from linearity was assessed by a Wald test examining the null hypothesis that the coefficient of the second spline was equal to zero. 3 For the first time, current physical activity guidelines 1, 2, 4, 5 emphasize the value of short bouts of intermittent physical activity (e.g. VPA, defined as physical activity at an energy expenditure rate of at least six metabolic equivalents (METs) is a time-efficient way to achieve recommended physical activity levels and can lead to rapid cardiorespiratory adaptations. Introductionīased on existing prospective observational evidence, the 2020 World Health Organization Physical activity and sedentary behaviour guidelines 1 and the physical activity guidelines for Americans, 2nd Edition 2 each recommended 150–300 min of moderate-to-vigorous physical activity (MVPA), 75–150 min of vigorous physical activity (VPA), or a combination of both a week. See the editorial comment for this article ‘The hare and the tortoise: physical activity intensity and scientific translation’, by C. Physical activity, Mortality, Cardiovascular disease, Cancer, Vigorous intensity 27 (24, 30) bouts/week was associated with the lowest all-cause mortality. ![]() There was an inverse linear association between VPA frequency and CVD mortality. These associations were consistent for CVD and cancer incidence. The ‘minimal’ volume dose (50% of the optimal dose) was ∼15 (14.3, 16.3) min/week for all-cause and cancer mortality, and 19.2 (16.5, 21.9) min/week for CVD mortality. There was an inverse linear dose-response association of VPA with CVD mortality. The ‘optimal dose’ (nadir of the curve) was 53.6 (50.5, 56.7) min/week relative to the 5th percentile reference (2.2 min/week). ![]() The dose–response associations of VPA volume and frequency with mortality, and CVD and cancer incidence were examined after excluding events occurring in the first year. VPA volume (min/week) and frequency of short VPA bouts (≤2 min) were measured. A prospective study in 71 893 adults from the UK Biobank cohort with wrist-worn accelerometry.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |